Development of morphoea in rheumatoid arthritis treated with penicillamine.
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چکیده
منابع مشابه
temporal arteritis . as a presenting feature of Inflammation of the uveal tract
altered immunity, such as rheumatoid arthritis, and may be due to an effect on regulatory 1' lymphocyte function.7 Evidence in support of T cell mediation as a second possible mechanism for the induction of morphoea by penicillamine is illustrated by the cases of two patients who developed-morphoea following bone marrow transplants8 after initial development of acute and chronic skin changes of...
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The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis patients treated with 250-750 mg/day D-penicillamine, 14 with a normal platelet count and 9 with thrombocytopenia (platelet count 50-130 X 10(9)/1). Age matched control patients not treated with D-peni...
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Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications of penicillamine therapy in patients with rheumatoid arthritis. A patient who had developed all 5 is now described. The skin lesion resembled elastosis perforans serpiginosa, which has been reported as a rare side effect in patients with Wilson's disease but not in ...
متن کاملPenicillamine in the treatment of rheumatoid arthritis.
Between 1973 and 1979, 203 patients with classical or definite rheumatoid arthritis were treated with chloroquine phosphate, gold, or penicillamine. Of 132 receiving penicillamine, 76 received it as the sole treatment. Forty of 50 withdrawals from penicillamine were side effect-related, although 4 of these 50 subsequently resumed therapy. Nineteen showed no response to penicillamine. Eight-six ...
متن کامل[D-penicillamine in the treatment of rheumatoid arthritis].
Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patie...
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عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 48 11 شماره
صفحات -
تاریخ انتشار 1989